Rocky Mountain Spotted Fever -- United States
Tetracyclines are broad-spectrum antimicrobials in use since the 1940s. Older tetracycline-class drugs have been linked to cosmetic staining of permanent teeth when used in children before the age of 8 years. As a result, in 1970 a warning label was attached to all tetracycline-class antibiotics advising against the use in children under the age of 8 years.
In 1967 doxycycline was introduced as a newer tetracycline-class antibiotic. Doxycycline binds less readily to calcium and has not been
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