HIV/AIDS -- United States
"CRISPR-associated protein 9 (Cas9)-mediated genome editing provides a promising cure for HIV-1/AIDS; however, gene delivery efficiency in vivo remains an obstacle to overcome. Here, we demonstrate the feasibility and efficiency of excising the HIV-1 provirus in 3 different animal models using an all-in-one adeno-associated virus (AAV) vector to deliver multiplex single-guide RNAs (sgRNAs) plus _Staphylococcus aureus_ Cas9 (saCas9). The quadruplex sgRNAs/saCas9 vector outperformed the duplex
Read more about it at HealthMap Global Disease Alerts via http://bit.ly/2q3uuH5
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